The Worsley and Eccles South constituency is located in the North West of England and has been formed from the former seats of Worsley and parts of Eccles following a review by the Boundary Commission for England. It includes the wards of Barton, Boothstown and Ellenbrook, Cadishead, Irlam, Little Hulton, Walkden North, Walkden South, Winton and Worsley.

Worsley town is renowned for its 'pastoral beauty', and its canal is lined with timbered buildings dating from the 19th century, including the Court House and Worsley Old Hall. Worsley's economy used to be focused on weaving but now it is a commuter town along with increased tourism activities.

Boothstown and Walkden are now residential areas, but were historically strong in coal mining and textiles. The ward of Irlam has a strong farming community to the north and residential areas to the south. Much industrial development took place along the canal banks and the Irlam Steelworks, opened in 1910, were a major source of local employment and economic stability until their closure in 1979. A diversified Industrial Estate has now been developed on the site of the former steelworks.

Little Hulton has undergone a resurgence in recent years. The main school in Little Hulton – Harrop Fold High – flourished under the Labour government, going from special measures at the beginning of the decade to a brand new building and consistently improving results.

A famous local feature in the constituency is the Bridgewater canal, which was open by 1765, and is famous for being orange in colour, due to the network of underground canals which run for many miles from picturesque Worsley village.